95% OF DISEASES HAVE

ZERO

TREATMENTS.

Is it OK if we allocate 1% of our apocalypse monies to curing them?

THE QUESTION

Adjust slider to show how you'd split your country's finite resources between the weapons and military vs to cure diseases.

50%
Military & Weapons
VS
50%
Clinical Trials

2 BILLION PEOPLE ARE

SUFFERING

FROM CURABLE DISEASES

FOR 2 REASONS:

REASON 1.

The Current System of Clinical Research Is Slow and Terrible

💰

82x Higher Costs Than Necessary

Everything costs 82x times more than it should. Efficiency is for other industries.

👥

$41K Cost Per Participant

It costs $41K to include one person in a study. That's more than most people make in a year.

💸

$2.6B Development Cost

To make one new drug costs $2.6B. Then they charge sick people to pay it back.

☠️

21K-120K Preventable Deaths

Between 21,000 and 120,000 people die every decade because the paperwork takes too long.

🚫

86.1% of Patients Excluded

86.1% of sick people can't join trials. Apparently they're not sick in the right way.

💊

95% of Diseases Untreated

95% of diseases have no cure. We're really good at the other 5%, though.

🤒

14 Years of Suffering

It takes 14 years from 'we found a cure!' to actually getting it. Most of us will be dead by then.

⚛️

45.1B Untested Treatments

45.1B possible cures exist. We've tested approximately none of them.

🌍

2.4B People Suffering

2.4B people are sick right now. The system is working exactly as designed.

🧫

44+ Years Since Last Disease Cure

We haven't cured a major disease in 44 years. But don't worry, we're very busy.

REASON 2.

GOVERNMENTS SPEND

604X MORE ON WAR

THAN CLINICAL TRIALS TO DISCOVER NEW TREATMENTS FOR DISEASES

MILITARY
$2.72T
$2.72T FOR
MASS MURDER CAPACITY
CLINICAL TRIALS
$4.5B
$4.5B FOR
CLINICAL TRIALS

WE CAN SOLVE BOTH OF THESE PROBLEMS SIMULTANEOUSLY

OXFORD RECOVERY TRIAL PROVED RESEARCH CAN BE DONE FOR

$500
PER PATIENT IN PRAGMATIC TRIALS
VS
$41K
PER PATIENT IN STANDARD TRIALS

Why The Bottleneck Is Clinical Trials, Not Basic Science

The Vast Unexplored Therapeutic Frontier

Known Safe Compounds
FDA-approved drugs + GRAS substances already proven safe in humans
Possible Combinations
9500 compounds × ~1,000 diseases
Actually Tested
Approved uses + repurposed + failed trials
99.7%
OF DRUG-DISEASE COMBINATIONS NEVER TESTED
Only 0.34% of the therapeutic frontier has been explored. The treatments may already exist among known-safe compounds - we just haven't tested them.
Exploration Ratio=32.5K tested9.5M possible=0.34%\text{Exploration Ratio} = \frac{\text{32.5K tested}}{\text{9.5M possible}} = 0.34\%
Therapeutic Frontier Explored
TESTED (0.34%)
UNEXPLORED (99.7%)

That tiny line on the left? That's ALL of modern medicine.

You cannot have "diminishing returns" when you haven't even started.

Wait, it gets worse: The FULL therapeutic frontier

The 9.5M figure above only counts single drugs against diseases. Modern medicine increasingly uses combination therapies (standard in oncology, HIV, cardiology).

Single Drugs × Diseases
What we showed above
Drug Pairs × Diseases
Combination therapy space
Emerging Modalities
Gene therapy, mRNA, cell therapy
Total Therapeutic Frontier
That's 45.1B combinations we could test. We've tested about 32.5K. Do the math on "diminishing returns."

Note: We use the conservative 9.5M figure in our main calculations because single-drug trials are more straightforward. But the combination therapy space shows the true scale of unexplored medicine.

Years to Universal Treatment Coverage

The Core Problem
6,650
Diseases Without Effective Treatment
~15
First Treatments Discovered Per Year
At current clinical trial capacity
443
Years to Cover All Diseases
6,650 ÷ 15/yr
Status Quo

Clinical trials are how we discover which treatments work for which diseases. At current trial capacity, we find first effective treatments for only ~15 diseases per year.

443 Years
To find treatments for all 6,650 diseases
That's longer than recorded human history
222 Years
Average wait for any single disease
If you have an untreated disease, you'll likely wait ~222 years for a first effective treatment
With $27.2B/yr Pragmatic Trials

Pragmatic trials cost ~44× less than traditional trials. This funding enables 12× more trials = ~180 first treatments per year.

36 Years
To cover all 6,650 diseases
443 years ÷ 12× capacity = 36 years
Addressing the "Diminishing Returns" Argument

Critics argue: "Just funding more trials won't proportionally increase discoveries - we've picked the low-hanging fruit."

This is wrong for six reasons:

1.
We haven't picked the fruit at all.
99.7% of drug-disease combinations are unexplored. You can't have diminishing returns when you haven't started.
2.
The bottleneck is trials, not candidates.
9.5K safe compounds sit untested. The limiting factor isn't discovering molecules - it's the capacity to test them.
3.
40% of promising drugs die from COST, not science.
The "Valley of Death" kills 40% of promising candidates not because they don't work, but because testing is too expensive. That's not diminishing returns - that's artificial scarcity.
4.
When we DO test old drugs, 30% find new uses.
Drug repurposing has a 30% success rate - triple the 10% rate of new drug development. The low-hanging fruit is literally everywhere.
5.
The treatment gap is real and growing.
6,650 diseases have no treatment. At ~15 first treatments/year, we'll never catch up. With 12× more trials, we actually have a shot.
6.
More trials = compounding returns, not diminishing.
Every trial teaches us more about biology. More data → better target selection → higher success rates. AI/ML models trained on trial data improve predictions. The more we test, the better we get at testing.

Diminishing returns apply to repeated attempts at the same problem. We're proposing to attempt problems we've never tried.

Two Possible Futures

This timeline shows how soon we could find a first treatment for all 6,650 untreated diseases. Under the status quo (~15 new treatments/year), it takes 443 years. With increased pragmatic trial funding, we can accelerate discovery dramatically.

Make It Personal
Enter your age to see if treatments arrive on time
years old
You Are Here
Year 0 - Choose Your Destiny
🎉
Yay! Treatments for most diseases discovered
Due to increased trial capacity (37 years)
Now see unnecessary death & suffering on the status quo timeline below
🪦
YOU

Treatments exist. Safe compounds exist. Patients are waiting.

The missing ingredient is trial capacity. That's a logistics problem, not a scientific frontier.

THE 1% TREATY
Would REDIRECT
1% OF GLOBAL MILITARY SPENDING
TO RADICALLY ACCELERATE MEDICAL PROGRESS BY ALLOWING ANY PATIENT TO PARTICIPATE IN PRAGMATIC TRIALS
MILITARY
$2.693T
1% REDUCTION 👉
GOV. CLINICAL TRIALS
$31.7B
$4.5B CURRENT
👈+$27.2B INCREASE FROM 1% TREATY
DON'T WORRY.
with the remaining $2.693T, WE'D STILL HAVE ENOUGH BULLETS, MISSILES, AND NUCLEAR BOMBS TO KILL EVERY MAN, WOMAN, AND CHILD ON EARTH 19 TIMES
(which should be more than sufficient)

WHAT $27.2B COULD BUY

41K+
HYPER-EFFICIENT PRAGMATIC TRIALS
INTEGRATED INTO STANDARD HEALTHCARE
23M+
PATIENTS TREATED
WITH THE MOST PROMISING NEW THERAPIES
TREATMENTS
FOR EVERY DISEASE
95% OF DISEASES HAVE ZERO FDA-APPROVED TREATMENTS
1%
FEWER BOMBS
POINTED AT EVERYONE

A decentralized framework for drug assessment

See what the platonic ideal of healthcare and clinical trials will look like when dFDA frameworks are widely adopted.

These are educational interface examples, not medical advice or a promise that every option is available. Treatment decisions stay with patients and licensed clinicians.

How it Works For Patients

Find the Most Promising Treatment for Your Condition

Search for trials based on your condition, location, and preferences.

  • Access trials from anywhere in the world
  • Filter by condition, treatment type, and more
  • See real-time availability and enrollment status
  • Compare multiple treatment options side-by-side
Alzheimer's
Comparative Effectiveness Rankings
Click any treatment to view available trials
Lecanemab (Leqembi)
FDA Approved
92%
Donanemab
Phase 3
88%
Aducanumab (Aduhelm)
FDA Approved
76%
Experimental Tau Inhibitor
Phase 2
72%
Memantine + Donepezil
FDA Approved
68%
APOE4 Gene Therapy
Phase 2
65%
Neuroinflammation Modulator
Phase 2
61%
Donepezil (Aricept)
FDA Approved
58%
Memantine (Namenda)
FDA Approved
52%
Rivastigmine (Exelon)
FDA Approved
49%
Galantamine (Razadyne)
FDA Approved
47%
Stem Cell Therapy
Phase 1
45%
GLP-1 Receptor Agonist
Phase 2
42%

View Outcome Labels

Review comprehensive outcome data before deciding to join a trial.

  • See real effectiveness data from actual patients
  • Understand potential side effects and their frequency
  • Compare with standard of care treatments
  • Read about experiences from patients like you
Klotho-Increasing Gene Therapy
Cognitive Improvements (Example)
Cognitive Function (ADAS-Cog)
+28%
Memory Recall
+35%
Executive Function
+22%
Hippocampal Volume
+15%
Side Effects (Example)
Immune Response
+12%
Headache
+9%
Fatigue
+7%

Join a Trial

Complete informed consent and enroll in your chosen trial.

  • Simple digital enrollment process
  • Clear explanation of trial requirements
  • Transparent compensation information
  • Easy withdrawal option if needed
Informed Consent
I understand that I am enrolling in a clinical trial for a new Alzheimer's disease treatment.
I have reviewed the outcome label
I understand the potential risks
I agree to share my anonymized data
Complete Enrollment

Coordinate Your Care

Schedule lab tests, provider visits, and import your health records.

  • Book appointments with just a few clicks
  • Import data from your existing health records
  • Attend virtual check-ins from anywhere
  • Receive reminders for upcoming appointments
Your Care Schedule
Cognitive Assessment
Neurology Center
May 15, 2023
9:30 AM
Virtual Check-in
Dr. Robert Chen, Neurologist
May 22, 2023
2:00 PM
Join Now
Import Health Records
Schedule New Appointment

Track Your Data

Record your diet, treatment adherence, symptoms, and more.

  • Simple mobile app for daily tracking
  • Automatic data collection from wearables
  • Customized tracking based on your trial
  • Secure and private data storage
Daily Tracking
Cognitive Function
Today's score:
/ 30
Medication Taken
Morning dose
Evening dose
Daily Activities
Completed memory exercises
Completed physical activity

Gain Personal Insights

View personalized analytics about your health and treatment response.

  • See how your response compares to others
  • Identify patterns in your symptoms and triggers
  • Track your progress over time
  • Receive personalized recommendations
Your Treatment Response
Cognitive Function Trend
↑ 15%
Apr 1Apr 7
Insight
Your cognitive function scores improve on days following social activities.
Recommendation
Consider taking your medication in the evening to reduce the daytime fatigue you've reported.

Connect with Your FDAi AI Agent

Receive personalized daily check-ins from your FDAi AI agent that monitors your progress, collects data, and provides insights in a conversational way.

  • Daily check-ins via phone or text to monitor your well-being
  • Natural conversation interface for easy data collection
  • Personalized insights based on your treatment response
  • Immediate alerts for potential side effects or concerns
  • Medication reminders and adherence support

FDAi Agent

Your personal health assistant

Good morning, Sarah! How are you feeling today after your treatment yesterday?

I'm feeling better today. The headache is gone but I still feel a bit tired.

That's good progress! Your fatigue has decreased by 40% since last week. Would you like to see how your symptoms compare to others in your trial?

Yes, please show me.

Daily check-ins help track your progress and provide personalized insights

How it Works For Providers

Review AI-Ranked Trial Matches for Your Patients

Our AI analyzes patient EHR data to identify and rank the most suitable and effective clinical trials, saving you time.

  • Leverage AI for precise patient-trial matching
  • View ranked lists based on predicted effectiveness
  • Quickly assess eligibility criteria against patient data
  • Focus on the most promising options first
Patient: John Doe (ID: P12345)
Top Trial Matches (Condition: Alzheimer's)
Lecanemab (Leqembi)
Recruiting
AI Match Score:
95%
Predicted Effectiveness:
92%
Donanemab Trial
Recruiting
AI Match Score:
91%
Predicted Effectiveness:
88%
APOE4 Gene Therapy
Recruiting
AI Match Score:
85%
Predicted Effectiveness:
65%
Neuroinflammation Modulator
Screening
AI Match Score:
82%
Predicted Effectiveness:
61%

Assign Patients to Trial Arms with Confidence

Review detailed outcome labels, compare trial arms (including placebo/standard of care), and assign patients directly.

  • Make informed decisions with transparent outcome data
  • Compare effectiveness and side effect profiles easily
  • Assign patients to specific trial arms seamlessly
  • Integrate assignment with patient management workflows
Lecanemab Trial - Patient: J. Doe
Arm 1: Lecanemab (Bi-weekly IV)Active
Cognitive Function (ADAS-Cog)+28%
Key Side Effects:
Immune Response (ARIA)12%
Arm 2: Placebo (Bi-weekly IV)Control
Cognitive Function (ADAS-Cog)-5%
Key Side Effects:
Headache5%

Monitor Patient Progress & Trial Performance

Track key metrics, patient-reported outcomes, and overall trial status through an intuitive dashboard.

  • Visualize patient progress over time
  • Monitor adherence and adverse events easily
  • Track enrollment rates and trial milestones
  • Generate reports for analysis and regulatory needs
Lecanemab Trial Dashboard
Enrollment Progress42 / 100 Patients
Patient Group Performance (ADAS-Cog Avg. Change)
+28%
Lecanemab Arm
-5%
Placebo Arm
Recent Adverse Events

P12345: Mild ARIA reported

P67890: Headache (resolved)

How it Works For Researchers

The new and improved FDA.gov would make it effortless for researchers to create a trial and invite patients to join.

Create a Trial

Upload protocols, pre/post-clinical data, and register your supply chain through the FDA.gov V2's intuitive interface.

  • Simple protocol builder with templates
  • Automated regulatory compliance checks
  • Secure data storage and management
Create New Trial
Upload Protocol

Get Liability Insurance

Automatically receive and select liability insurance quotes per subject with transparent pricing.

  • Competitive quotes from multiple providers
  • Risk-based pricing tailored to your trial
  • One-click policy activation
Select Liability Insurance
SafeTrial Liability Insurance
Comprehensive coverage
Recommended
Per participant:$45
MedSecure Plus
Basic coverage
Per participant:$32

Set Parameters

Define patient pricing, required data collection, and refundable deposits to optimize your trial.

  • Flexible pricing models for participants
  • Customizable data collection requirements
  • Incentive structures to maximize retention
Trial Parameters
USD
%
Blood GlucoseWeightActivityDiet

Manage Supply Chain & Orders

Track inventory, fulfill patient orders, and manage the entire treatment supply chain with end-to-end visibility.

  • Automated inventory tracking and alerts
  • Secure patient order processing and fulfillment
  • Temperature-controlled shipping monitoring
  • Blockchain-verified chain of custody
Supply Chain Dashboard
Inventory Status
In Stock
1,250 units
Allocated
840 units
Recent Orders
#ORD-2845
2 units • Processing
New
#ORD-2844
1 unit • Shipped
Delivered
Supply Chain Map
Interactive map view

Analyze Trial Data

Access real-time insights, analyze effectiveness data, and make informed decisions with comprehensive dashboards and reporting tools.

  • Real-time effectiveness monitoring
  • Participant compliance tracking
  • Advanced statistical analysis tools
  • Regulatory submission preparation
Trial Analytics Dashboard
Trial Performance
Effectiveness graph
Patient Compliance
Overall Rate
92%
Submissions
4,265
Adverse Events
Total Reports
12
Requires Review
3

💰 THE MATH

The Returns on Not Dying

When you stop making people fill out paperwork and start letting them not die, something magical happens:

RETURN ON INVESTMENT

$637 returned for every $1 invested

Not a typo. Not a fever dream. Actual math.

This beats humanity's previous greatest hits in the "not dying" genre:

1% Treaty
637:1
Smallpox Eradication
280:1
Childhood Vaccinations
13:1

WHERE THE VALUE COMES FROM:

ANNUAL RESEARCH SAVINGS
Drug trials cost 82x less
QALYS GAINED ANNUALLY
Quality-adjusted life years

Value comes from faster drug approvals (14 years → 2 years), better treatment matching through real-world data, and addressing neglected diseases that companies ignore.

♾️ The Math That Broke Excel

A 84.8M:1 Return on Investment

A $1B campaign yields $84.8 Quadrillion in health value.

ROI=Health Value CreatedCampaign Cost=$84.8Quadrillion$1B=84.8M:1\begin{aligned} \text{ROI} &= \frac{\text{Health Value Created}}{\text{Campaign Cost}} \\[1em] &= \frac{\$84.8 Quadrillion}{\$1B} = 84.8M:1 \end{aligned}

Where The Value Comes From:

Campaign Cost
Total investment needed
Health Value
From timeline acceleration
Lives Saved
From treatments arriving earlier
/yr
R&D Savings
Per year, forever

Math says this is the best possible use of a billion dollars.

Math is rarely wrong about money. People are frequently wrong about money.

SEE THE FULL MATH →

Charts, breakdowns, and all the nerdy details

THE QUESTION

Adjust slider to show how you'd split your country's finite resources between the weapons and military vs to cure diseases.

50%
Military & Weapons
VS
50%
Clinical Trials

YOUR VOTE'S IMPACT

2.6
LIVES SAVED PER VOTE

/year scales trial capacity 12X, achieving 247 years of progress in 20

Through a 212-year average timeline shift: 12× trial capacity + eliminating 8.2-year regulatory delays

53
YEARS SUFFERING PREVENTED
$20.5M
ECONOMIC VALUE
30s
TO VOTE

Highest ROI Action in History

In 30 seconds, you can save more lives than most people save in a lifetime.

💀 DEATH CLOCK

0
PEOPLE DIED TODAY
0
PEOPLE DIED THIS YEAR
while we waste billions building nuclear bombs 💣☢️ and skynet 🤖
SUFFERING: OPTIONAL
SOLUTION: PROVEN
COST: 1% OF MURDER BUDGET
ACTION: REQUIRED
TIME: NOW
MAKING SUFFERING OPTIONAL THROUGH MATH
The International Campaign to End War and Disease